Talaporfin sodium-mediated photodynamic therapy alone and in combination with pulsed dye laser on cutaneous vasculature

Authors: K. M. Kelly, W. J. Moy, A. J. Moy, B. S. Lertsakdadet, J. J. Moy, E. Nguyen, A. Nguyen, K. E. Osann and B. Choi
Journal: Journal of Investigative Dermatology 135: 302-304 (2015)

Currently, standard treatment for port wine stain (PWS) birthmarks in the United States involves the use of lasers or intense pulsed light to photocoagulate selectively the abnormal vasculature. With photothermal therapy, PWS often become lighter, but patients must undergo many treatments. Furthermore, treatment of skin types IV-VI is difficult owing to absorption of light by overlying epidermal melanin, limiting treatment safety and efficacy. Photodynamic therapy (PDT), an alternative option, involves optical excitation of photosensitizers localized primarily within the intravascular component which enables targeted vascular destruction. Treatment can be effective but it is associated with prolonged photosensitivity and substantial scarring risk. Talaporfin sodium (TS) is a photosensitizer with proven selective vascular effects in preclinical studies. The authors test the hypothesis that dual phototherapy treatment with TS-mediated PDT and ensuing pulsed dye laser (PDL) therapy will achieve persistent vascular shutdown with lower radiant exposures of either PDT or PDL irradiation.

Dual phototherapy represents a potential new approach for more effective treatment of PWS birthmarks. The authors have initiated a trial approved by the Investigational Review Board to evaluated intravenously administered TS/664-nm laser light-mediated dual phototherapy for PWS treatment. Completion of this study will determine whether lesion lightening is greater with dual phototherapy than PDL alone. It is the authors’ intent that this combined low-energy dual phototherapy will offer clinicians and patients of all skin types improved lesion lightening in fewer treatments.