UCI Multimodality Intravascular Imaging Team Wins ICTS Science Award

The UC Irvine (UCI) Multimodality Intravascular Imaging Team has won the 2015 Robert Newcomb Interdisciplinary Team Science Award given by The Institute for Clinical and Translational Science (ICTS). The Intravascular Imaging Team is a transdisciplinary collaboration of three groups of investigators from three institutions: OCT group (Dr. Zhongping Chen from the Department of Biomedical Engineering at UCI); IVUS group (Dr. Qifa Zhou from the NIH Transducer Resource Center at University of Southern California); and Interventional Cardiology group (Dr. Pranav Patel from the Department of Medicine and Division of Cardiology at UCI Medical Center). The Intravascular Imaging Team evolved from the common goal to develop an integrated intravascular imaging modality that can detect, diagnose, and manage vulnerable plaques to prevent the lethal consequences of atherosclerosis.

Dr. Chen leads UC Irvine’s optical coherence tomography research group which developed fundamental imaging systems that integrated OCT and other imaging modalities with complementary imaging contrast. Dr. Zhou from USC provides expertise in miniature ultrasound transducers and ultrasound imaging systems. Dr. Patel and his cardiology team leads in understanding the clinical problems and challenges, as well as providing guidance and development of in vivo animal studies and clinical protocols. Together, they have addressed the problem of designing and constructing a new intravascular imaging platform that integrates intravascular ultrasound (IVUS), optical coherence tomography (OCT), photoacoustic tomography (PAT), and acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution of OCT, broad imaging depth of US, molecular contrast of PAT, and tissue mechanical contrast of ARF-OCE. This multimodality intravascular imaging system will provide clinicians with a critically important tool for diagnosing vulnerable plaques, monitoring the progression of disease, and evaluating the efficacy of intervention.

Team members include: Jiawen Li, M.S., Ph.D. student, Biomedical Engineering, UCI; Teng Ma, M.S., Ph.D. student, Biomedical Engineering, USC; Dilbahar Mohar, M.D., Cardiology fellow, UCIMC; Earl Steward, Staff Research Associate, UCIMC; Rachel Qu, M.S., Ph.D. student, Biomedical Engineering, UCI; Ryan Jonathan-William Burris, M.D., Internal medicine resident, UCIMC; and Zhu Jiang, Ph.D., postdoctoral fellow, Beckman Laser Institute.

The team will be honored at the ICTS Awards Dinner on May 12, 2015.